Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine Neoplasia

Neuroendocrine tumors of the gastro-entero-pancreatic system.

Gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs) are rare neoplasms, although their prevalence has increased substantially over the past three decades. Moreover, there has been an increased clinical recognition and characterization of these neoplasms. They show extremely variable biological behavior and clinical course. Most NETs have endocrine function and secrete peptides and neuro...

OctreoScan® scintigraphy for gastro- entero-pancreatic neuroendocrine tumours

Molecular markers associated with response to chemotherapy in gastro-entero-pancreatic neuroendocrine tumors.

Response rates to cytotoxics in gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) vary; recent trials demonstrated lack of objective response rates in up to 70% of patients. Identification of predictive therapeutic biomarkers would be beneficial in the treatment of GEP. Selected markers with known or suspected capability of predicting response to cytotoxics or prognosis (Ki-67, p53, mul...

Screening for malnutrition in patients with gastro-entero-pancreatic neuroendocrine tumours: a cross-sectional study

OBJECTIVES To investigate whether screening for malnutrition using the validated malnutrition universal screening tool (MUST) identifies specific characteristics of patients at risk, in patients with gastro-entero-pancreatic neuroendocrine tumours (GEP-NET). DESIGN Cross-sectional study. SETTING University Hospitals Coventry & Warwickshire NHS Trust; European Neuroendocrine Tumour Society C...

GEP-NETS update: a review on surgery of gastro-entero-pancreatic neuroendocrine tumors.

The incidence of neuroendocrine tumors (NETs) has increased in the last decades. Surgical treatment encompasses a panel of approaches ranging from conservative procedures to extended surgical resection. Tumor size and localization usually represent the main drivers in the choice of the most appropriate surgical resection. In the presence of small (<2 cm) and asymptomatic nonfunctioning NETs, a ...